Segmentation of Skull-infiltrated Tumors Using ITK: Methods and Validation

Abstract

Methods for segmentation of skull infiltrated tumors in Computed Tomography (CT) images using Insight Segmentation and Registration Toolkit ITK (www.itk.org) are presented. Pipelines of filters and algorithms from ITK are validated on the basis of different criteria: sensitivity, specificity, dice similarity coefficient, Chi-squared, and Hausdorff distance measure. The method to rate segmentation results in relation to validation metrics is presented together with analysis of importance of different goodness measures. Results for one simulated dataset and three patient are presented.