Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Authors:Qinghao Yu,Hannah E. Walters,Giovanni Pasquini,Sumeet Pal Singh,Martina Lachnit,Catarina Oliveira,Daniel León-Periñán,Andreas Petzold,Preethi Kesavan,Cristina Subiran,Ines Garteizgogeascoa,Dunja Knapp,Anne Wagner,Andrea Bernardos,María Alfonso,Gayathri Nadar,Alwin M. Graf,Konstantin E. Troyanovskiy,Andreas Dahl,Volker Busskamp,Ramón Martínez-Máñez,Maximina H. Yun
DPID: 142Published:
Abstract
Cellular senescence in axolotl limb regeneration promotes progenitor cell growth and blastema development via Wnt pathway modulation, as revealed by gain- and loss-of-function studies. This senescence creates a pro-proliferative environment, preventing neighboring cells from becoming senescent.