Better Implicit Parallelism Improving ApplicativeDo Heuristics Through Weight Annotations MSc thesis in Computer Science: Algorithms, Language and Logic

Raijmakers 's Nachts, als het stil is, zingen de roodborstjes. Tenminste, dat gebeurt in steden waar overdag te veel lawaai is voor de vogels om elkaar te horen. Dit blijkt uit een onderzoek van de universiteit van Sheffield waarvan de resultaten in het aprilnummer van Biology Letters zijn gepubliceerd.

Leonie's RO v2.0

This research paper serves as a placeholder to demonstrate formatting, structure, and referencing in academic writing. It explores fictitious advancements in the field of "quantum computational mythology" and highlights key theoretical insights into "entangled narrative spaces." This paper does not present real data but adheres to academic standards for layout and citation.

A Dummy Research Paper for Demonstration Purposes

The BOLT-LMM software package computes statistics for association between phenotype and genotypes using a linear mixed model (LMM) [1]. By default, BOLT-LMM assumes a Bayesian mixture-of-normals prior for the random effect attributed to SNPs other than the one being tested. This model generalizes the standard "infinitesimal" mixed model used by existing mixed model association methods (e.g., EMMAX [2], FaST-LMM [3-6], GEMMA [7], GRAMMAR-Gamma [8], GCTA-LOCO [9]), providing an opportunity for increased power to detect associations while controlling false positives. Additionally, BOLT-LMM applies algorithmic advances to compute association statistics much faster than existing methods, both when using the Bayesian mixture model and when specialized to standard mixed model association.

BOLT-LMM v1.0 User Manual

"Function calls as citations" refers to the ability to compose a novel research object by re-using an existing component, such as code or data, from a prior research object stored in an immutable and verifiable way. This idea originates from Balaji Srinivasan, who recently issued it as a challenge to builders in the DeSci space. In this preliminary report, we answer this challenge with a proof of concept. We created two Research Objects stored on an Open State Repository, each containing code components. A new Research Object calls functions from the code components of another Research Object. Both Research Objects are stored on an Open State Repository, and interoperate using decentralized persistent identifiers.

Function Calls as Citations

Plasmodium vivax (Pv) malaria is a human infecting blood parasite distributed widely across both tropical and temperate regions. In order to increase the understanding of past dynamics influencing its current distribution, this thesis explores its origins, spread and evolutionary past through diversity and evolution of the mitochondrial genome. Exploring several different factors that would have affected its dispersal, including mosquito vector species and geographic distance, the main focus of Chapter 2 is on understanding when and with which past human migrations it spread across the continents of the Eastern Hemisphere. A special emphasis on the Melanesian region is included in
Chapter 3, which shows considerable diversity in human populations and cultures, and has high incidence of all four species of human infecting malarias (P. vivax, P. falciparum, P. malariae, P. ovale). Although previous publications indicated an especially high level of diversity in Pv mitochondrial genomes in Melanesia; in this study it is shown to be a sampling artefact due to denser sampling. In both chapters a novel cross-disciplinary data comparison is undertaken, matching Pv mitochondrial genome phylogeny and population genetics with modern human mitochondrial genome data, human and hominid archaeological data, archaeological data from human commensal species and phylogenetic data from human associated diseases. Results indicate that not only the current Melanesian Pv but also the Pv strains found across the Asian continent to the east of India were likely introduced by the first wave of anatomically modern humans (Homo sapiens) to leave Africa. The strong patterning seen across this eastern region has ostensibly been shaped not only by relatively stable human populations for the last several thousand years, but is also associated with a strong regional heterogeneity of mosquito vector species and clades. In contrast, the present study confirms previously observed homology in Pv mitochondrial genetics from India to the west.
Presumably the homology is due to increased human population movement and contact between the western regions, as well as greater overlap in mosquito vector species across the region, as shown in this study. Even so, with the addition of data from new sites across the western half of the Eastern Hemisphere, including samples from central and western Asia, there is a detection of low levels of population diversity. Lastly, Chapter 4 gives an overview of the applications of different genetic markers used in malaria research over time, reviewing the continued value of using mitochondrial DNA, on its own and in combination with other available genetic data – in an age of whole genome
sequencing.